Scale up Filtration Calculations

Settling Test

Procedure : Take ~ 100 ml slurry mass and settle for 3 min.

Obsevation and conclusion :

If settles down less 10 minutes --> Good to filter

If settles down before 30 min & cloudy mass --> Medium Filterability and use preferable centrifuge or high-pressure filter

If settles down in or above 30 min & cloudy mass --> difficult to filter, crystallization conditions need to be altered

 

Filtration rate test :

Procedure :

Using slurry mass (to be filtered) prepare ~ 5 cm cake thickness over Buckner filter paper.Charge ~100 ml slurry over the 5 cm cake bed and apply vacuum (NLT 650 mm Hg. Measure the time required to filter the mass in seconds.

Obsevation and conclusion :

If ML filters at a rate of > 40 lpm/m2 -->Good to filter

If ML filters at a rate of < 20 lpm/m2 -->Difficult to filter, crystallization conditions need to be altered